Clinical study on nasopharyngeal cancer with unexpected result

14-Nov-2022

Patients with nasopharyngeal cancer are often treated with drugs that activate their immune system against the tumor. Until now, it was feared that vaccination against Covid-19 could reduce the success of cancer treatment or cause severe side effects. A recent study by the Universities of Bonn ...

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Study elucidates an important immune mechanism

02-Nov-2022

Hemophilia A is the most common severe form of hemophilia. It affects almost exclusively males. The disease can usually be treated well, but not for all sufferers. A study at the University of Bonn has now elucidated an important mechanism that is crucial for making the therapy effective. The ...

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Study follows an innovative path in the search for new active substances

22-Sep-2022

The zebrafish serves as a model organism for researchers around the world: it can be used to study important physiological processes that also take place in a similar form in the human body. It is therefore routinely used in the search for possible active substances against diseases. Researchers ...

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"If we could correct faulty sites in the genetic code with RNA editing methods, this would potentially also offer starting points for the treatment of hereditary diseases"

21-Sep-2022

If everything is to run smoothly in living cells, the genetic information must be correct. But unfortunately, errors in the DNA accumulate over time due to mutations. Land plants have developed a peculiar correction mode: they do not directly improve the errors in the genome, but rather ...

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Hope for new treatment options

29-Jul-2022

In severe Covid-19 patients, the metabolism produces insufficient amounts of certain energy-rich compounds called ketone bodies. However, these energy carriers are needed by two important cell types in the immune system in order to fight the virus effectively. Perhaps this finding explains why ...

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Study identifies a new signaling molecule that increases the energy consumption of brown fat cells

07-Jul-2022

A study led by the University of Bonn has identified a molecule - the purine inosine - that boosts fat burning in brown adipocytes. The mechanism was discovered in mice, but probably exists in humans as well: If a transporter for inosine is less active, the mice remain significantly leaner ...

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Results from the University of Bonn raise hope for new drugs against cancer and brain diseases

29-Mar-2022

The A2A receptor regulates how vigorously the innate immune system attacks diseased cells. Researchers at the University of Bonn have now been able to show for the first time how an important inhibitor binds to the receptor. In the future, the results will facilitate the targeted search for ...

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Researchers specifically stimulate the RNA receptor RIG-I, which improves protection against lethal SARS-CoV-2 infections

18-Mar-2022

SARS-CoV-2 viruses can hide from recognition by the immune system. However, the antiviral immune receptor RIG-I can be stimulated, which improves protection against lethal SARS-CoV-2 infections. Researchers led by Prof. Gunther Hartmann from the Institute of Clinical Chemistry and Clinical ...

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Study suggests errors in the interpretation of older measurements

08-Feb-2022

A few years ago, a novel measurement technique showed that protons are probably smaller than had been assumed since the 1990s. This surprised the scientific community; some researchers even believed that the Standard Model of particle physics would have to be changed. Physicists at the University ...

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Study could provide medicine with a powerful therapeutic tool

07-Feb-2022

Researchers at the Universities of Bonn and Regensburg have elucidated the structure of a central cellular inflammatory switch. Their work shows which site of the giant protein called NLRP3 inhibitors can bind to. This opens the way to develop new pharmaceuticals that could target inflammatory ...

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