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Researchers investigate structural changes in snap-frozen proteins

A novel method allows visualization of molecular motions lasting a few millionths of a second

03-May-2021

Researchers at the University of Bonn and the research center caesar have succeeded in ultra-fast freezing proteins after a precisely defined period of time. They were able to follow structural changes on the microsecond time scale and with sub-nanometer precision. Owing to its high spatial and ...

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COVID-19 has multiple faces

Scientists present latest findings on the coronavirus

20-Jan-2021

According to current studies, the COVID-19 disease which is caused by the SARS-CoV-2 coronavirus comprises at least five different variants. These differ in how the immune system responds to the infection. Researchers from the German Center for Neurodegenerative Diseases (DZNE) and the University ...

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Customized programming of human stem cells

The results open new possibilities in research

02-Dec-2020

Induced pluripotent stem cells (iPS) have the potential to convert into a wide variety of cell types and tissues. However, the "recipes" for this conversion are often complicated and difficult to implement. Researchers at the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden, Harvard ...

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Genetic disposition protects immune system from aging

Study reveals a previously unknown function of a human gene

11-Nov-2020

A genetic disposition that plays a role in the development of the heart in the embryo also appears to play a key role in the human immune system. This is shown by a recent study led by the University of Bonn. When the gene is not active enough, the immune defense system undergoes characteristic ...

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New method allows precise gene control by light

Study enhances research toolbox with a new tool with great potential

02-Oct-2020

A novel optical switch makes it possible to precisely control the lifespan of genetic "copies". These are used by the cell as building instructions for the production of proteins. The method was developed by researchers from the universities of Bonn and Bayreuth. It may significantly advance the ...

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A "corset" for the enzyme structure

Structure of biocatalysts depends on whether they are in cells or in the test tube

29-Apr-2020

The structure of enzymes determines how they control vital processes such as digestion or immune response. This is because the protein compounds are not rigid, but can change their shape through movable "hinges". The shape of enzymes can depend on whether their structure is measured in the test ...

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How cells recognize uninvited guests

16-Apr-2020

Until now, the immune sensor TLR8 has remained in the shadows of science. A research team led by the University of Bonn has now discovered how this sensor plays an important role in defending human cells against intruders. The enzymes RNaseT2 and RNase2 cut ribonucleic acids (RNAs) of bacteria ...

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Activation of opioid receptor uncovered

29-Nov-2019

Together with colleagues from Shanghai, Brussels, Canada and the USA, researchers from the University of Bonn have uncovered the binding mechanism of an important pain receptor. The results facilitate the development of new active substances. The opioids used today to treat severe pain can be ...

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Epilepsy: Function of "brake cells" disrupted

04-Oct-2019

In some forms of epilepsy, the function of certain "brake cells" in the brain is presumed to be disrupted. This may be one of the reasons why the electrical malfunction is able to spread from the point of origin across large parts of the brain. A current study by the University of Bonn, in which ...

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How Artificial Intelligence Detects Rare Diseases

11-Jun-2019

Every year, around half a million children worldwide are born with a rare hereditary disease. Obtaining a definitive diagnosis can be difficult and time consuming. In a study of 679 patients with 105 different rare diseases, scientists from the University of Bonn and the Charité - ...

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