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Study shows how bioactive substance inhibits important receptor

Results from the University of Bonn raise hope for new drugs against cancer and brain diseases

29-Mar-2022

The A2A receptor regulates how vigorously the innate immune system attacks diseased cells. Researchers at the University of Bonn have now been able to show for the first time how an important inhibitor binds to the receptor. In the future, the results will facilitate the targeted search for ...

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New strategy for COVID-19 prophylaxis

Researchers specifically stimulate the RNA receptor RIG-I, which improves protection against lethal SARS-CoV-2 infections

18-Mar-2022

SARS-CoV-2 viruses can hide from recognition by the immune system. However, the antiviral immune receptor RIG-I can be stimulated, which improves protection against lethal SARS-CoV-2 infections. Researchers led by Prof. Gunther Hartmann from the Institute of Clinical Chemistry and Clinical ...

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Protons are probably actually smaller than long thought

Study suggests errors in the interpretation of older measurements

08-Feb-2022

A few years ago, a novel measurement technique showed that protons are probably smaller than had been assumed since the 1990s. This surprised the scientific community; some researchers even believed that the Standard Model of particle physics would have to be changed. Physicists at the University ...

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Structure of central inflammation switch elucidated

Study could provide medicine with a powerful therapeutic tool

07-Feb-2022

Researchers at the Universities of Bonn and Regensburg have elucidated the structure of a central cellular inflammatory switch. Their work shows which site of the giant protein called NLRP3 inhibitors can bind to. This opens the way to develop new pharmaceuticals that could target inflammatory ...

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Stem cells organize themselves into embryoid

Study of mice could enable alternative methods to animal experiments in the medium term

21-Dec-2021

Researchers at the University of Bonn have developed a method to generate embryo-like cell complexes from the stem cells of mice. The method provides new insights into embryonic development. In the medium term, it might also be suitable for developing tests for substances that could be harmful to ...

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New group of antibacterial molecules identified

International research group discovers promising scaffold for antimicrobial agents

19-Nov-2021

Researchers at Karolinska Institutet, Umeå University, and the University of Bonn have identified a new group of molecules that have an antibacterial effect against many antibiotic-resistant bacteria. Since the properties of the molecules can easily be altered chemically, the hope is to develop ...

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Epigenetics: Immunisation is passed on to offspring

22-Oct-2021

Does an infection also affect the immunisation of subsequent generations? Researchers at Radboud University (Netherlands) have investigated this together with the Universities of Bonn, Saarland, Lausanne (Switzerland) and Athens (Greece). Mouse sires that had previously overcome infection with ...

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Immune cells in the brain share the work

This cooperation is impaired in mutations that can cause Parkinson's disease

24-Sep-2021

To break down toxic proteins more quickly, immune cells in the brain can join together to form networks when needed. This is shown by a joint study of the University of Bonn, the German Center for Neurodegenerative Diseases (DZNE) and the Institut François Jacob in France. However, in certain ...

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Persistent dysfunction in natural killer cells has been implicated in severe COVID-19 progressions

14-Sep-2021

Based on previous studies of the COVID-19 pandemic, it is known that a specific form of white immune cells, natural killer (NK) cells, make an important contribution to the early antiviral immune response against SARS-CoV-2. An international team led by the University of Bonn has now found that ...

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New substance classes for nanomaterials

Nano spheres and diamond slivers made of silicon and germanium

09-Sep-2021

Chemists at Goethe University Frankfurt have developed two new classes of materials in the field of nanomaterials and investigated them together with their cooperation partners at the University of Bonn: for the first time, they have succeeded in producing a nano sphere of silicon atoms and a ...

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