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"Immortality protein" fires up the cell's power plants

Protection against the consequences of heart attacks

01-Nov-2021

The aging researchers Prof. Judith Haendeler from the Medical Faculty and the molecular biologist Prof. Joachim Altschmied from the Department of Biology together with their teams have shown for the first time in the cardiovascular system that Telomerase Reverse Transcriptase (TERT) within the ...

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How resistant germs transport toxins at molecular level

Results could help develop mechanisms to combat dangerous pathogens

22-Sep-2021

In order to counter the increasing threat posed by multi-drug resistant germs, we need to understand how their resistance mechanisms work. Transport proteins have an important role to play in this process. In an article published in the journal Nature Communications, a German/UK research team led ...

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Tiny sensors for major advances

Using NMR spectrometry to analyse important molecules that have not been accessible before now

18-May-2021

An international research team involving the working group of biophysicist Dr. Manuel Etzkorn from Heinrich Heine University Düsseldorf (HHU) has developed an approach for using NMR spectrometry to analyse important molecules that have not been accessible before now. In the journal Angewandte ...

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Release of Drugs from a Supramolecular Cage

“The special trick with our system involves the pre-determined rupture points”

10-May-2021

How can a highly effective drug be transported to the precise location in the body where it is needed? In the journal Angewandte Chemie, chemists at Heinrich Heine University Düsseldorf (HHU) together with colleagues in Aachen present a solution using a molecular cage that opens through ...

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Artificial ‘candy canes’ block viruses

Synthetic glycomimetics attach to the viruses’ binding sites, which viruses normally use to attach to sugars on the cell surface

22-Apr-2020

Synthetic chains of molecules containing different sugars can inhibit viruses effectively. The extent to which such molecules could be used as antiviral drugs is illustrated by a team of researchers from Heinrich Heine University Düsseldorf (HHU) and University of Münster (WWU) in the February ...

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Research into Parkinson’s disease: binding-protein prevents fibril proliferation

04-Sep-2019

Several neurodegenerative diseases such as Parkinson’s are closely linked to the aggregation of a specific protein, α-synuclein. An international collaborative project involving Heinrich Heine University Düsseldorf (HHU), Forschungszentrum Jülich (FZJ) and RWTH Aachen University has now shed ...

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Biological risk potential of nanoparticles studied

28-Aug-2019

Carbon nanoparticles are a promising tool for biomedical applications, for example for targeted transportation of biologically active compounds into cells. A team of researchers from the Physics, Medicine and Chemistry departments at Heinrich Heine University Düsseldorf (HHU) has now examined ...

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Assemblies of proteins relevant not only for Alzheimer’s and Parkinson’s disease

23-Aug-2019

Amyloid fibrils play a crucial role in neurodegenerative illnesses. Scientists from Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich have now been able to use cryo-electron microscopy (cryo-EM) to decode the spatial structure of the fibrils that are formed from PI3K SH3 ...

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New anti-malarial lead compound successfully tested

09-Aug-2017

Researchers in a team headed by Professor Thomas Kurz at the Institute of Pharmaceutical and Medicinal Chemistry of Heinrich Heine University Düsseldorf (HHU) have successfully tested an optimised lead compound in animal experiments that acts against plasmodia, i.e. malaria parasites. Lead ...

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