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29 Current news of Universität Zürich
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Mechanism for DNA Invasion of Adenoviral Covid-19 Vaccines Discovered
Premature release of DNA activates anti-viral alarm systems
23-Dec-2021
Adenoviruses have a linchpin protein that stabilizes their DNA until it reaches the infected cell’s nucleus. The protein then detaches from the viral genome, and the virus uncoats. Only then are the genes released into the nucleus, which is necessary for the production of new viruses. This ...
Microscopy Deep Learning Predicts Viral Infections
Automatic detection of virus-infected cells - solely on the fluorescence of the cell nucleus
23-Jun-2021
When viruses infect cells, changes in the cell nucleus occur, and these can be observed through fluorescence microscopy. Using fluoresence images from live cells, researchers at the University of Zurich have trained an artificial neural network to reliably recognize cells that are infected by ...
Lipid Metabolism Controls Brain Development
Diminished stem cell activity reduces cognitive performance
11-May-2020
A lipid metabolism enzyme controls brain stem cell activity and lifelong brain development. If the enzyme does not work correctly, it causes learning and memory deficits in humans and mice, as researchers at the University of Zurich have discovered. Regulating stem cell activity via lipid ...
Newly Discovered Protein Gives Signal for Virus Infection
19-Dec-2019
Researchers at the University of Zurich have discovered a protein that enables adenoviruses to infect human cells. The Mib1 protein gives the virus the signal to uncoat the DNA and release it into the nucleus. Blocking this protein could therefore help people with weakened immune systems to fight ...
Antibiotics with Novel Mechanism of Action Discovered
25-Oct-2019
Many life-threatening bacteria are becoming increasingly resistant to existing antibiotics. Swiss researchers co-headed by the University of Zurich have now discovered a new class of antibiotics with a unique spectrum of activity and mechanism of action – a major step in the fight against ...
Drug resistance: Preventing drugs from being transported
18-Jun-2019
Certain membrane proteins specialise in transporting molecules out of cells – a problem for the efficacy of cancer medication and antibiotics. An international research team has investigated the transport mechanism of a bacterial membrane protein using an artificially produced antibody fragment. ...
Simple and Fast Method for Radiolabelling Antibodies against Breast Cancer
Using UV light, radiolabelled antibodies can be produced in just 15 minutes
24-Apr-2019
Radioactive antibodies that target cancer cells are used for medical diagnostics with PET imaging or for targeted radioimmunotherapy. Researchers from the University of Zurich have created a new method for radiolabelling antibodies using UV light. In less than 15 minutes, the proteins are ...
Precise Decoding of Breast Cancer Cells Creates New Option for Treatment
17-Apr-2019
Researchers at the University of Zurich and from IBM Research have investigated the varying composition of cancer and immune cells in over one hundred breast tumors. They've found that aggressive tumors are often dominated by a single type of tumor cell. If certain immune cells are present as ...
Water that never freezes
12-Apr-2019
Can water reach minus 263 degrees Celsius without turning into ice? Yes it can, say researchers from ETH Zurich and the University of Zurich, if it is confined in nanometre-scale lipid channels. Making ice cubes is a simple process: you take a plastic ice-cube tray like you’d find in most ...
Bat Influenza Viruses Could Infect Humans
22-Feb-2019
Bats don’t only carry the deadly Ebola virus, but are also a reservoir for a new type of influenza virus. These newly discovered flu viruses could potentially also attack the cells of humans and livestock, researchers at the University of Zurich have now shown. Seasonal outbreaks of the flu are ...
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