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20 Current news about the topic crisprrss
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Verification in a living system
The causes of the disease are for the most part obscure. Researchers intend to expose them using cerebral organoids grown from stem cells. In the majority of cases, dementia can be traced back to Alzheimer’s disease. Its causes are not really understood yet. What is known is that plaques form ...
mRNA of defective genes pushes compensation mechanism
Many diseases are caused by genetic defects. However, their severity can vary among individual patients, so that even mild forms can occur. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now decrypted a molecular mechanism responsible for this phenomenon. ...
Limiting the impact of schistosomiasis and liver fluke infection
For the first time, researchers at the George Washington University (GW), together with colleagues at institutes in Thailand, Australia, the U.K. and the Netherlands, and more, have successfully used the gene-editing tool CRISPR/Cas9 to limit the impact of parasitic worms responsible for ...
Drug screening with Mobile-CRISPRi
A University of Wisconsin-Madison researcher and his collaborators at the University of California, San Francisco have repurposed the gene-editing tool CRISPR to study which genes are targeted by particular antibiotics, providing clues on how to improve existing antibiotics or develop new ...
Experimental therapy could repair mutations that cause genetic diseases
A new technology that relies on a moth-infecting virus and nanomagnets could be used to edit defective genes that give rise to diseases like sickle cell, muscular dystrophy and cystic fibrosis. Rice University bioengineer Gang Bao has combined magnetic nanoparticles with a viral container drawn ...
Two Arizona State University professors are among the first recipients ofSomatic Cell Genome Editing (SCGE) grants from the National Institutes of Health Common Fund. The $2,600,000, five-year grant will fund the first study of the genome editing technology CRISPR to be used on a "human liver ...
A team of researchers from ETH Zurich and the University Children’s Hospital Zurich applied a newly developed editing tool to target and correct genetic mutations. By doing so, the researchers healed mice suffering from a genetic metabolic disorder that also affects humans. Parents of newborns ...
Researchers develop new CRISPR/Cas process using Japanese ricefish
The molecular tool CRISPR/Cas allows introducing DNA double strand breaks into any gene of interest consequently resulting in stochastic mutations at the site of the target gene. However, precise gene repair through the application of a rescue construct suffers from limited efficiency. ...
Method giving complete spatiotemporal control and treads DNA lightly
A major obstacle to in-cell genome editing is, well, the cell itself.“Human cells don’t like to take in stuff,” explained UC Santa Barbara’s Norbert Reich, a professor in the Department of Chemistry and Biochemistry. The human cell has evolved a “trash disposal” mechanism that isolates and breaks ...
Biochemists discover cause of genome editing failures
Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. CRISPR is a gene-editing tool that allows scientists to cut out unwanted genes or genetic material from DNA, ...
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