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Cell cultures in the third dimension

Printable elastic silicone carrier systems for 3D cell cultures

For chemicals and pharmaceutical products that are brought to the market, meaningful toxicological data needs to be ascertained. While, to the present day, animal experiments play a key role in this task, the challenge is to replace them with high-validity tests carried out in organoid cell ...

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Scientist – Teacher – Service provider

Carl Remigius Fresenius (1818–1897), a pioneer of analytical chemistry

On December 28, 2018, Carl Remigius Fresenius would have celebrated his 200th birthday (Fig. 1.) Not only was he a scientist but also an innovative entrepreneur as well as the teacher of about 5,000 students during the more than fifty years of his pioneering, enduring professional work. It is ...

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The fingerprint of the diatom

Multi-elemental analysis of diatoms using single-cell-ICP-TOF-MS

In today’s laboratories, elemental analysis methods are used for more than just determining total metal content in various sample matrices. They have become an important tool for life science research in environmental science, medicine and biology.

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Mercury in the environment

A comparison of different analysis techniques for determination and species analysis of mercury

Mercury is undisputedly one of the most toxic elements. In 2013, the Minamata Convention on Mer-cury to restrict the production and emission of this heavy metal was adopted in Geneva. It regulates the production, use and storage of mercury. For example, new mines may no longer be built and ...

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Coffee – A world of variety

Using photoionization mass spectrometry for online analysis and control of the coffee roasting process

Turning green coffee into roasted brown beans conjures myths, trends and desires. From the small gourmet roaster to the industrial plant, the growing consumer interest in quality and variety has increased the need to understand and influence the processes that take place when coffee is being ...

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How to analyze active unknown unknowns?

Discovering compounds that matter for food safety along the global food chain

More than ever, consumers are concerned about the food they consume. For example, for botanical extracts used in food products and food supplements, fraud is quite common. It is evident that specifications, quality control and regulation of botanicals need to be improved [1-3].

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Weighing in the US Pharmacopeia

Minimum Weight and Routine Testing According General Chapters 41 and 1251

Weighing is one of the key activities carried out in every QC laboratory. Usually, it is one of the first parts of a whole analysis chain. As any weighing errors have the potential to propagate through the whole analysis and deliver an inaccurate final result, the United States Pharmacopeia (USP) ...

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Surprisingly simple molecules as potential OLED-Emitters?

Improving the efficiency of organic light emitting diodes with aromatic carbonyls

Organic light emitting diodes (OLEDs) are presently conquering the market for displays of smartphones and TVs. They also have a great potential in lighting applications. Current devices for the blue part of the visible spectrum lag behind their green and red counterparts in terms of efficiency ...

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Assessing the lung toxicity of air pollutants

Automated exposure of human lung cells at the air-liquid interface

The current debates on driving bans in European cities show not only how important air quality is to the public but also reveal the lack of available methods to directly assess the adverse effects of air pollutants on human health.

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Light plus current: The formula for researching what happens to individual nanoparticles

Electrochemical dark-field microscopy can visualize and help investigate the reactions of individual nanoparticles

A combination of dark-field microscopy and electrochemistry can make individual nanoparticles in a liquid medium visible. The technique is suited to determine the activity of catalysts during their use.

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