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8 q&more articles about the topic chromatography

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HPLC with non-specific detection in pharmaceutical quality control

Smart sample preparation improves selectivity of analytical procedures for biopharmaceuticals and other drug products

Impurity testing is an essential part of pharmaceutical quality control because toxicity and content of impurities contained in drug products can impair patient safety. This requires suitable, validated analytical methods.

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Workflow

ICH Linearity Studies using Automated Standard Preparation and UHPLC

According to the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH), it is necessary to test analytical methods for their linearity as part of a method validation study. The typical process for this is to prepare standards ...

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Pollutants in ocean-floor sediment

New measurement methods to protect the marine environment

What kinds of contaminants are enriched in sediment – and are these then absorbed by the organisms that live there? What role do microplastics play? To answer these questions, Professor Gesine Witt’s team is using pollutant samplers made from silicone-coated glass fibre to investigate the sea ...

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Staying power

Adhesives modeled on insect secretions

Geoscientists, biologists and chemists at the University of Tübingen are working in collaboration with IFAM (Fraunhofer Institute for Manufacturing Technology and Advanced Materials in Bremen, Germany) to uncover the workings of insect surface adhesion. The goal of this project is the synthesis ...

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Combinatorial explosion in separation sciences

New approaches for high quality information

In analytical sciences one of the major goals is to develop and validate methods for the identification and quantification of molecules in complex samples to support investigations in the pharmaceutical sciences, environmental sciences, food sciences, biology and medicine.

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Molecules in the mirror

Enantiomer separation using capillary electrophoresis

In 1871 the children‘s book “Through the Looking-Glass – And What Alice Found There” by the English author Lewis Carroll, in which Alice enters a world behind the mirror, was published. She explains to her cat: “First there’s the room you can see through the glass – that’s just the same as our ...

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A Complex Mixture

Automated MOSH/MOAH determination with the aid of coupled LC-GC

Once only of academic interest, the combination of liquid chromatographic separation with subsequent separation in the gas-phase is proving to be suitable for routine use. In routine laboratory work, the method continues to present a major challenge, above all with regard to precision, ...

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The Third Dimension

Protein analysis using multidimensional liquid chromatography with monolithic phases and mass spectrometry

Proteins play a fundamental role in our day-to-day lives. Thanks to proteins we can speak, move about and think; they protect us from disease and repair damage to our bodies. Proteins are also becoming more popular as active pharmaceutical ingredients: in 2012, the market share of ...

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