A catalyst with high selectivity for converting organolithium compounds

For the first time, an efficient catalyst for palladium-catalyzed C–C bonding between aryl chlorides and alkyl lithium compounds has been found. This reaction enables simpler synthesis routes for important products, such as pharmaceuticals, while avoiding much salt waste.

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Microstructured, aqueous solutions allow for a photocatalytic activation of alkyl chlorides

Photoredox catalysis has developed into a powerful tool for the synthesis of organic compounds with diverse structures. However, the high stability of carbon-chloride bonds has long hampered the use of cheap and readily available chloroalkanes as substrates.

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A new chapter in the book of life for a sustainable bioeconomy

Despite his love for complex molecular architectures, this „dyed-in-the-wool“ bio-organic chemist has never embraced the conventional segregation of synthetic polymers and bio­logical macromolecules. All molecules are composed of atoms, after all. Why make an artificial distinction? Why not ...

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Efficient synthesis of an anti-malarial agent in a continuous-flow microreactor

Malaria represents a global threat to health, which is difficult to keep under control. Amongst more than 200 million sufferers, over 500,000 die each year of the disease, with the risk of a fatal outcome being particularly high in children [1].

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Or The End of the Beginning?

Those of us who have been either directly involved in, or on the periphery of, the pharmaceutical industry over the last decade have seen at first hand a dramatic change. Times change, and technology changes. Take computer data storage for example. Not so long ago, the floppy disk was state of ...

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