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Bioreactor control system for precise fermentation in biopharma applications

Reliable gravimetric feed control using balances

Application note: Bioreactor gravimetric feed control. Reliable dosing using balances

It is vital to control conditions such as temperature, pH, cell density, and dissolved oxygen in the bioreactors where the organisms grow in order to produce pharmaceuticals, vaccines or antibodies or to convert raw materials into other useful products.

Exemplary illustration of a pH control system of a bioreactor with pH Meter, control unit, peristaltic pump, and balance for gravimetric feed control of pH buffer.

Bioreactor control system with gravimetric feed is an efficient method for precise fermentation in biopharma applications. With the increasing need for accurate and consistent fermentation processes in the biopharmaceutical industry, the need for rapid, simple, compliant, and cost-efficient bioreactor process control becomes a key factor for success. A bioreactor feed control system based on adding liquids by weight rather than by volume is a proven method that ensures highly precise fermentation.

This application note outlines how Mettler-Toledo precision balances can control the flow of liquids into a bioreactor in a simple control loop involving the bioreactor, the pump and the balance. This control loop is established via seamless integration among the instruments. With gravimetric feed control using a balance, you can be sure of efficient, accurate, and reliable process control with a minimum amount of investment – resulting in more efficient research and development processes.

Facts, background information, dossiers

  • bioreactors
  • fermentation process
  • gravimetric feed control
  • research and development
  • weighing technology

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