In the laboratory, weighing is only one step of a whole analysis chain in quality control; however it strongly influences the overall quality and integrity of the final result. In production, weighing is mandatory to achieve batch uniformity and consistency in dispensing or formulation processes. In all industries, accurate weighing is essential to ensure continuous adherence to predefined process requirements and to avoid a frequent source of Out of Specification results (OOS). This paper introduces GWP®, the science-based global standard for efficient lifecycle management of weighing instruments. Based primarily on the user’s weighing requirements and prevailing weighing risks, it provides a state-of-the-art strategy for reducing measurement errors and ensuring accurate weighing results.